β-胡萝卜素, 96%|Natrual β-Carotene|cas:7235-40-7|西域试剂

β-胡萝卜素, 96%,Natrual β-Carotene

产品编号：西域试剂-WR360889| CAS NO：7235-40-7| MDL NO：MFCD00001556| 分子式：C₄₀H₅₆| 分子量：536.87

β-Carotene (Provitamin A) 属于类胡萝卜素化合物，是天然存在的维生素 A 前体。β-Carotene 是一种 ROS 调节剂，具有抗氧化和抗炎活性。β-Carotene 可作为抗氧化剂或者促氧化剂，取决于它的内在特性以及它所作用的生物环境的氧化还原电位。 β-Carotene 可诱导乳腺癌细胞凋亡 (apoptosis)，具有抗癌活性。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
西域试剂-WR360889	￥65.00	杭州北京（现货）
西域试剂-WR360889	￥156.00	杭州北京（现货）
西域试剂-WR360889	￥596.00	杭州北京（现货）
西域试剂-WR360889	￥1990.00	杭州北京（现货）
西域试剂-WR360889	￥4804.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

产品名称

β-胡萝卜素, 96%

英文名称

Natrual β-Carotene

CAS编号

7235-40-7

产品描述

产品熔点

178-179ºC

产品沸点

654.7±22.0 °C at 760 mmHg

产品密度

0.9±0.1 g/cm3

产品闪点

346.0±17.2 °C

精确质量

536.438232

LogP

15.51

外观性状

深红色或暗红色、有光泽的斜方六面体或结晶状粉末

蒸气压

0.0±0.9 mmHg at 25°C

折射率

1.566

溶解性

Souble in DMSO ,Acetone，THF

溶解性数据

In Vitro:

THF : 12.5 mg/mL (23.28 mM; ultrasonic and warming and heat to 60°C)

Acetone : 5 mg/mL (9.31 mM; Need ultrasonic)

DMSO : 1 mg/mL (1.86 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8626 mL	9.3132 mL	18.6265 mL
5 mM	0.3725 mL	1.8626 mL	3.7253 mL
10 mM	0.1863 mL	0.9313 mL	1.8626 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

靶点

Human Endogenous Metabolite

体外研究

β-Carotene up-regulates PPAR-γ expression and ROS production in MCF-7 cancer cells.
β-Carotene (1-100 μM; 72 hours) remarkably decreases the survival of MCF-7 cells in a dose-dependent manner.
β-Carotene (50 μM; 24-72 hours) significantly enhances the expression levels of PPAR-γ mRNA and protein in a time-dependent manner.
β-Carotene down-regulates the COX-2 but up-regulates the p21 mRNA level and protein expression in a time dependent manner.
β-Carotene significantly increases the percentage of early apoptosis and the effect was partly attenuated by pre-incubation with GW9662 (HY-16578) or GSH (HY-D0187).
β-Carotene induces cytochrome C release.

XIYU has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	MCF-7 cells
Concentration:	1 μM, 10 μM, 20 μM, 50 μM, 100 μM
Incubation Time:	72 hours
Result:	Decreased the numbers of viable cells to 70% and 50% at 20 μM and 50 μM, respectively.

RT-PCR

Cell Line:	MCF-7 cells
Concentration:	50 μM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Up-regulated the PPAR-γ mRNA.

Western Blot Analysis

Cell Line:	MCF-7 cells
Concentration:	50 μM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Up-regulated PPAR-γ protein expression levels.

Apoptosis Analysis

Cell Line:	MCF-7 cells
Concentration:	50 μM
Incubation Time:	72 hours
Result:	Induced MCF-7 cells apoptosis.

动物实验

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.8626 mL	9.3132 mL	18.6265 mL
5 mM	0.3725 mL	1.8626 mL	3.7253 mL
10 mM	0.1863 mL	0.9313 mL	1.8626 mL

不同实验动物依据体表面积的等效剂量转换表（参考来源于公开文献）

	小鼠	大鼠	兔	豚鼠	仓鼠	狗
重量 (kg)	0.02	0.15	1.8	0.4	0.08	10
体表面积 (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m 系数	3	6	12	8	5	20

动物 A (mg/kg) = 动物 B (mg/kg) ×	动物 B的K_m系数
	动物 A的K_m系数

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

稳定性

1. 在橄榄油和苯中的溶解度均为0.1g/mL，在氯仿中的溶解度为4.3g/100mL，高浓度时呈橙红色，低浓度时呈橙色至黄色。在pH值2～7的范围内较稳定，且不受还原性物质的影响，但对光和氧均不稳定，铁离子会促使其褪色。

2. 存在于烤烟烟叶、白肋烟烟叶中。

3. 是自然界中存在最普遍、最稳定的天然色素。

储存条件

密封于−20°C阴凉干燥处。

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

补充危害声明	Risk of explosion if heated under confinement.
个人防护装备	Eyeshields;Gloves
危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	R44
安全声明 (欧洲)	S7-S15-S18
危险品运输编码	NONH for all modes of transport
WGK德国	1
RTECS号	FI0329500
包装等级	II; III
危险类别	4.1
海关编码	2932999099

1. 物质的识别

产品名：	β-Carotene
CAS号：	7235-40-7
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	β-Carotene
别名：	Provitamin A; Carotaben; beta-Carotene; Lucarotin
分子式：	C40H56
分子量：	536.87

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	-20°C, protect from light, dry, sealed

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

上游产品 9
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870636-68-3 116-31-4 15647-89-9 870636-64-9
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下游产品 10
514-78-3 991-90-2 17092-92-1 7500-42-7
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