Benproperine phosphate 磷酸苯丙哌林|cas:19428-14-9|西域试剂

Benproperine phosphate 磷酸苯丙哌林,99.23%

产品编号：Bellancom-114657A| CAS NO：19428-14-9| 分子式：C₂₁H₃₀NO₅P| 分子量：407.44

Benproperine phosphate 是一种具有口服活性的，有效的肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。Benproperine phosphate 通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。Benproperine phosphate 有潜力用于止咳，并可以抑制癌细胞迁移和肿瘤转移。

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-114657A		￥500.00	杭州北京（现货）

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Benproperine phosphate 磷酸苯丙哌林

产品介绍

Benproperine phosphate 是一种具有口服活性的，有效的肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。Benproperine phosphate 通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。Benproperine phosphate 有潜力用于止咳，并可以抑制癌细胞迁移和肿瘤转移。

生物活性

Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis.

体外研究

Benproperine phosphate (20-120 μM; for 24 hours) inhibits cell viability in a dose-dependent manner.
Benproperine phosphate (10 μM; for 24 hours) significantly inhibits the migration of various types of cancer cells and inhibits the migration and invasion of DLD-1, AsPC-1 cells with IC₅₀ values of 1-2 μM. Benproperine phosphate (10 μM; for 24 hours) does not affect cortactin-rich lamellipodium in MCF-10A cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	DLD-1, AsPC-1, CFPAC-1, A375P, A375P, MDA-MB-231, DU145, DU145 cancer cells
Concentration:	20, 40, 60, 80, 100, 120 μM
Incubation Time:	For 24 hours
Result:	Inhibited cell viability in a dose-dependent manner.

体内研究
(In Vivo)

Benproperine phosphate (50, 100 mg/kg; oral gavage; 5 days per week for 4 weeks) inhibits primary pancreatic tumor growth.
Benproperine phosphate shows a marked decrease in the lung metastasis of AsPC-1 cells (56.1% inhibition) in mouse. Benproperine phosphate significantly suppressed the liver metastasis of HCT-116 cells by 78.9% and DLD-1 cells by 78.2%.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c nude mice of 6-week-old with AsPC-1 cells
Dosage:	50, 100 mg/kg
Administration:	Oral gavage; 5 days per week for 4 weeks
Result:	Inhibited primary pancreatic tumor growth compared to the vehicle control (47.7% inhibition) without body weights change.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c nude mice of 6-week-old with AsPC-1 cells
Dosage:	50, 100 mg/kg
Administration:	Oral gavage; 5 days per week for 4 weeks
Result:	Inhibited primary pancreatic tumor growth compared to the vehicle control (47.7% inhibition) without body weights change.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female BALB/c nude mice of 6-week-old with AsPC-1 cells
Dosage:	50, 100 mg/kg
Administration:	Oral gavage; 5 days per week for 4 weeks
Result:	Inhibited primary pancreatic tumor growth compared to the vehicle control (47.7% inhibition) without body weights change.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (613.59 mM; Need ultrasonic)

H₂O : ≥ 100 mg/mL (245.43 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4543 mL	12.2717 mL	24.5435 mL
5 mM	0.4909 mL	2.4543 mL	4.9087 mL
10 mM	0.2454 mL	1.2272 mL	2.4543 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (5.11 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (5.11 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (5.11 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (5.11 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (5.11 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (5.11 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在西域网站选购。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

. Yae Jin Yoon, et al. Benproperine, an ARPC2 inhibitor, suppresses cancer cell migration and tumor metastasis. Biochem Pharmacol. 2019 May;163:46-59. [Content Brief]

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Benproperine phosphate 磷酸苯丙哌林,99.23%

Benproperine phosphate 磷酸苯丙哌林

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