6,2'-Dihydroxyflavone 6,2-二羟基黄酮|cas:92439-20-8|西域试剂

6,2'-Dihydroxyflavone 6,2-二羟基黄酮,99.88%

产品编号：Bellancom-N6628| CAS NO：92439-20-8| 分子式：C₁₅H₁₀O₄| 分子量：254.24

6,2'-Dihydroxyflavone 是一个新型的 GABAA 受体拮抗剂。

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-N6628		￥600.00	杭州北京（现货）

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6,2'-Dihydroxyflavone 6,2-二羟基黄酮

产品介绍

6,2'-Dihydroxyflavone 是一个新型的 GABA_A 受体拮抗剂。

生物活性

6,2'-Dihydroxyflavone is a novel antagonist of GABA_A receptor.

体外研究

6,2'-Dihydroxyflavone is a novel antagonist of GABA_A receptor. 6,2'-Dihydroxyflavone inhibits [³H]-flunitrazepam binding to the rat cerebral cortex membranes with a K_i of 37.2±4.5 nM. The current elicited with the EC₅₀ concentration of GABA is decreased to 73.6±1.9% of control by co-application of 5 μM 6,2'-Dihydroxyflavone (n=5), compare to a decrease to 65.9±3.0% by 1 μM FG-7142 (n=5). The EC₅₀ for GABA dose response increases from 47.6 to 59.7 μM upon co-application of 5 μM 6,2'-Dihydroxyflavone, and the maximal GABA-current is decreased.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

6,2'-Dihydroxyflavone-treated mice exhibit significant differences from control mice with respect to the percentage of open arms entries [F_(4,73)=8.01, P<0.0001] and the percentage of time spent in open arms [F_(4,73)=5.19, P<0.002], but not the number of entries to closed arms [F_(4,73)= 0.79,P=0.54]. The post-hoc NewmaneKeuls’ tests confirm that 6,2'-Dihydroxyflavone significantly decreases the percentage of open arm entries and time spent in open arms at the doses of 8 and 16 mg/kg. 6,2'-Dihydroxyflavone treatment similarly increases step-through latency [F_(4,75)=4.71, P<0.002], suggesting enhanced cognitive performance.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (393.33 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.9333 mL	19.6665 mL	39.3329 mL
5 mM	0.7867 mL	3.9333 mL	7.8666 mL
10 mM	0.3933 mL	1.9666 mL	3.9333 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.83 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.83 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。