β-Casomorphin, bovine β-Casomorphin-7 (bovine; Bovine β-casomorphin-7)|cas:72122-62-4|西域试剂

β-Casomorphin, bovine β-Casomorphin-7 (bovine; Bovine β-casomorphin-7),99.83%

产品编号：Bellancom-P0179| CAS NO：72122-62-4| 分子式：C₄₁H₅₅N₇O₉| 分子量：789.92

β-casomorphin, bovine (β-casomorphin-7) 是阿片 (opioid) 活性的多肽，与阿片受体结合的 IC50 值为14 μM。

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货号	价格	库存与货期
Bellancom-P0179	￥800.00	杭州北京（现货）
Bellancom-P0179	￥1400.00	杭州北京（现货）
Bellancom-P0179	￥2900.00	杭州北京（现货）

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β-Casomorphin, bovine β-Casomorphin-7 (bovine; Bovine β-casomorphin-7)

产品介绍

β-casomorphin, bovine (β-Casomorphin-7 (bovine) ) 是阿片 (opioid) 活性的多肽，与阿片受体结合的 IC₅₀ 值为 14 μM。

生物活性

β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay.

体外研究

β-Casomorphin, bovine (0.1 μM; 30 minutes-24 hours) stimulates the secretion of mucin in DHE Cells after 8 h of treatment.
β-Casomorphin, bovine (0.1 μM; 24 hours) induces an increase in rMuc2 and rMuc3 mRNA levels.
β-Casomorphin, bovine do not modify the expression of rMuc1, rMuc4, and rMuc5AC.
β-Casomorphin, bovine (0.1 μM; 24 hours) stimulates MUC5AC expression and mucin Secretion in HT29-MTX Cells (human).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

β-Casomorphin, bovine (7.5×10⁻⁶ mol/day/kg ; i.g.; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats.
β-Casomorphin, bovine (7.5×10⁻⁶ mol/day/kg ; i.g.; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats.
β-Casomorphin, bovine (7.5×10⁻⁶ mol/day/kg ; i.g.; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats.
β-Casomorphin, bovine (7.5×10⁻⁶ mol/day/kg ; i.g.; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley (SD) rats (200 g±10 g)
Dosage:	7.5×10⁻⁶ mol/day/kg
Administration:	Oral gavage; for 30 days
Result:	Increased plasma insulin and decreased plasma glucagon of diabetic rats.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley (SD) rats (200 g±10 g)
Dosage:	7.5×10⁻⁶ mol/day/kg
Administration:	Oral gavage; for 30 days
Result:	Increased plasma insulin and decreased plasma glucagon of diabetic rats.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (126.60 mM; Need ultrasonic)

H₂O : ≥ 50 mg/mL (63.30 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.2660 mL	6.3298 mL	12.6595 mL
5 mM	0.2532 mL	1.2660 mL	2.5319 mL
10 mM	0.1266 mL	0.6330 mL	1.2660 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 25 mg/mL (31.65 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (3.16 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.16 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
3.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (3.16 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.16 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
4.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (3.16 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (3.16 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在西域网站选购。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

参考文献

. Brantl V, et al. Opioid activities of beta-casomorphins. Life Sci. 1981 Apr 27;28(17):1903-9. [Content Brief]

. Zoghbi S, et al. β-casomorphin-7-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13. [Content Brief]

. Zhang W, et al. The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro. PLoS One. 2013 May 3;8(5):e63472. [Content Brief]

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产品编号(Item Number)

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β-Casomorphin, bovine β-Casomorphin-7 (bovine; Bovine β-casomorphin-7),99.83%

β-Casomorphin, bovine β-Casomorphin-7 (bovine; Bovine β-casomorphin-7)

化学品安全说明书(MSDS)

质检证书(COA)

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