Polygalacturonic acid Galacturonic acid polymer|cas:25990-10-7|西域试剂

Polygalacturonic acid Galacturonic acid polymer,95.0%

产品编号：Bellancom-N6613| CAS NO：25990-10-7| 分子式：(C₆H₁₀O₇)x| 分子量：194.139

聚半乳糖醛酸（半乳糖醛酸聚合物）是透明胶体，是细胞壁的主要成分。聚半乳糖醛酸可用于制备银纳米粒子（AgNP），作为一种抗氧化剂和抗炎药，可保护细胞免受活性氧升高的破坏作用，并加速伤口愈合。聚半乳糖醛酸纳米粒也显示出抗菌活性。

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-N6613		￥300.00	杭州北京（现货）
Bellancom-N6613		￥550.00	杭州北京（现货）

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Polygalacturonic acid Galacturonic acid polymer

产品介绍

Polygalacturonic acid (Galacturonic acid polymer) 是透明胶状酸，是细胞壁的主要成分。Polygalacturonic acid 可用于制备银纳米颗粒 (AgNPs)，作为抗氧化剂和抗炎剂，保护细胞免受 ROS 升高的破坏作用，并加速伤口愈合。Polygalacturonic acid 纳米颗粒也表现出抗菌活性。

生物活性

Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity.

体外研究

Polygalacturonic acid can be used to format a durable hydrogel, to prolong the effect of drugs. Polygalacturonic acid hydrogel/hyaluronate, conjugated Ibuprofen (HY-78131) for example, prevents epidural fibrosis, the severe scar tissue adhesion of laminectomized male adult rats, and increases the efficiency of local inflammation control and reduces the side-effect of Ibuprofen.
Polygalacturonic acid hydrogel/hyaluronate (PGA-HA) (2%, 200 μL; 24 h) shows low cytotoxicity on L929 fibroblasts.
Polygalacturonic acid (PGA) preparing (Ag-PGA/HA)-PVA nanoparticles, shows anti-bacterial activity against gram-positive bacterial strains; Bacillus Subtilis and Staphylococcus Aureus, as well as gram-negative bacterial strain; Escherichia Coli.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Polygalacturonic acid (external application; 14 d) enhances a quick healing of wound infection in albino rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Full thickness wound model in albino rats (60-day-old, 180 g)
Dosage:	Ag-Polygalacturonic acid/hyaluronic acid nanoparticles
Administration:	Applied on dorsal muscle fascia; cleaned the wound daily with alcohol; for 14 days
Result:	Resulted no sign of abscess formation or hypertrophic scars both in the early phase; 5th day or in the final phase; 14th day, respectively. Showed significant wound healing from day 8 while treated with (Ag-PGA/HA)-PVA nanofiber and blank (PGA/HA)-PVA nanofiber and induced epithelization on day 14.

体内研究

Polygalacturonic acid (external application; 14 d) enhances a quick healing of wound infection in albino rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Full thickness wound model in albino rats (60-day-old, 180 g)
Dosage:	Ag-Polygalacturonic acid/hyaluronic acid nanoparticles
Administration:	Applied on dorsal muscle fascia; cleaned the wound daily with alcohol; for 14 days
Result:	Resulted no sign of abscess formation or hypertrophic scars both in the early phase; 5th day or in the final phase; 14th day, respectively. Showed significant wound healing from day 8 while treated with (Ag-PGA/HA)-PVA nanofiber and blank (PGA/HA)-PVA nanofiber and induced epithelization on day 14.

性状

Solid

溶解性数据

In Vitro:

H₂O : 5 mg/mL (ultrasonic and warming and heat to 60°C)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献

. Lin CY, et al. Ibuprofen-conjugated hyaluronate/polygalacturonic acid hydrogel for the prevention of epidural fibrosis. J Biomater Appl. 2016 May;30(10):1589-600. [Content Brief]

. El-Aassar MR, et al. Wound healing of nanofiber comprising Polygalacturonic/Hyaluronic acid embedded silver nanoparticles: In-vitro and in-vivo studies. Carbohydr Polym. 2020 Jun 15;238:116175. [Content Brief]

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Polygalacturonic acid Galacturonic acid polymer,95.0%

Polygalacturonic acid Galacturonic acid polymer

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