Terreic acid|cas:121-40-4|西域试剂

Terreic acid,99.0%

产品编号：Bellancom-110013| CAS NO：121-40-4| 分子式：C₇H₆O₄| 分子量：154.12

苯甲酸是一种醌类环氧化物抗生素，是一种有效的Btk抑制剂。土甲酸阻断PKC和Btk的pleckstrin同源结构域之间的相互作用。在IC50约为100μM的HMC-1人类肥大细胞的裂解物中，稀土酸抑制GST-BtkPH与PKC的结合。

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-110013		￥8200.00	杭州北京（现货）

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Terreic acid

产品介绍

Terreic acid 是一种醌环氧化物抗生素 (antibiotic)，是一种有效的 Btk 抑制剂。 Terreic acid 阻断 PKC 和 Btk 的 PH结构域之间的相互作用。 Terreic acid 作用于HMC-1 人肥大细胞裂解物，抑制 GST-BtkPH 与 PKC 结合，IC₅₀ 约为 100 μM。

生物活性

Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC₅₀ of approximately 100 μM.

体外研究

Terreic acid inhibits the association of Btk with PKCβII in mouse mast cells at lower concentrations (IC₅₀ of ≈30 μM). Terreic acid inhibits the catalytic activity of Btk but not PKC.
Terreic acid (pretreatment for 30 min before stimulation by antigen for 3 min) inhibits both the basal and activation levels of Btk autophosphorylating activity with IC₅₀s of 10 μM and 3 μM, respectively.
Terreic acid inhibits the autophosphorylating activity of Btk purified partially from recombinant baculovirus-infected Sf9 insect cells in a dose-dependent manner.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	Mouse bone marrow-derived mast cells
Concentration:	0, 5, 10, 20 μM
Incubation Time:	Pretreated for 30 min
Result:	Inhibited both the basal and activation levels of Btk autophosphorylating activity in a dose-dependent manner.

体内研究
(In Vivo)

Terreic acid inhibits the late-phase response of in vivo allergic cutaneous reactions.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c mice
Dosage:	0, 0.15, 1.5, and 15 mg/kg
Administration:	Injected i.p. 1 hr before antigen challenge. Ear thicknesses were measured at 1 hr and 24 hr
Result:	The early response, as examined 1 hr after antigen challenge, was not affected by TA. In contrast, TA inhibited the late-phase (24 hr) response in a dose-dependent manner.

体内研究

Terreic acid inhibits the late-phase response of in vivo allergic cutaneous reactions.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c mice
Dosage:	0, 0.15, 1.5, and 15 mg/kg
Administration:	Injected i.p. 1 hr before antigen challenge. Ear thicknesses were measured at 1 hr and 24 hr
Result:	The early response, as examined 1 hr after antigen challenge, was not affected by TA. In contrast, TA inhibited the late-phase (24 hr) response in a dose-dependent manner.

体内研究

Terreic acid inhibits the late-phase response of in vivo allergic cutaneous reactions.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c mice
Dosage:	0, 0.15, 1.5, and 15 mg/kg
Administration:	Injected i.p. 1 hr before antigen challenge. Ear thicknesses were measured at 1 hr and 24 hr
Result:	The early response, as examined 1 hr after antigen challenge, was not affected by TA. In contrast, TA inhibited the late-phase (24 hr) response in a dose-dependent manner.

性状

Solid

溶解性数据

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献

. Y Kawakami, et al. Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2227-32. [Content Brief]

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产品编号(Item Number)

批号(Lot Number)

符号	GHS07
信号词	Warning
危害声明	H302 + H312
警示性声明	P280
危险品运输编码	NONH for all modes of transport

Terreic acid,99.0%

Terreic acid

化学品安全说明书(MSDS)

质检证书(COA)

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