Sodium nitroprusside 硝普钠; Ro 21-2498|cas:14402-89-2|西域试剂

Sodium nitroprusside 硝普钠; Ro 21-2498,99.0%

产品编号：Bellancom-B0564| CAS NO：14402-89-2| 分子式：C₅FeN₆Na₂O| 分子量：261.92

Sodium Nitroprusside是血管舒张剂，能促使NO释放于血液中。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-B0564		￥500.00	杭州北京（现货）
Bellancom-B0564		￥800.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Sodium nitroprusside 硝普钠; Ro 21-2498

产品介绍

Sodium nitroprusside (Ro 21-2498) 是血管舒张剂，能促使 NO 释放于血液中。

生物活性

Sodium nitroprusside (Ro 21-2498) is a potent vasodilator working through releasing NO spontaneously in blood.

体外研究

Sodium nitroprusside (Ro 21-2498) is a potent vasodilator. Sodium nitroprusside has potent vasodilating effects in arterioles and venules. Sodium nitroprusside breaks down in circulation to release nitric oxide (NO). NO activates guanylate cyclase in vascular smooth muscle and increases intracellular production of cGMP. The end result is vascular smooth muscle relaxation, which allow vessels to dilate . Sodium nitroprusside decreases the proliferation of vascular smooth muscle cells . Sodium nitroprusside (5 mg/kg) significantly reduces the intestinal ischemiareperfusion injury as a nitric oxide donor in rats .

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (381.80 mM; Need ultrasonic)

DMSO : 33.33 mg/mL (127.25 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.8180 mL	19.0898 mL	38.1796 mL
5 mM	0.7636 mL	3.8180 mL	7.6359 mL
10 mM	0.3818 mL	1.9090 mL	3.8180 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (381.80 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (9.54 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.54 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
3.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (9.54 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.54 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在西域网站选购。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献

. Wink, D.A., et al., The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: a direct correlation between nitric oxide formation and protection. Arch Biochem Biophys, 1996. 331(2): p. 241-8. [Content Brief]

. Garg, U.C. and A. Hassid, Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest, 1989. 83(5): p. 1774-7. [Content Brief]

. Namazi, H., Sodium nitroprusside as a nitric oxide donor in a rat intestinal ischemia reperfusion model: a novel molecular mechanism. Clinics (Sao Paulo), 2008. 63(3): p. 405. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

相关产品

危害码 (欧洲)	T: Toxic;
风险声明 (欧洲)	25
安全声明 (欧洲)	45
危险品运输编码	UN 3288 6.1/PG 3
WGK德国	3
RTECS号	LJ8925000
包装等级	III
危险类别	6.1(b)

Name:	Sodium Nitroprusside Material Safety Data Sheet
Synonym:	Disodium nitrosylpentacyanoferrate; nipride; nitroprussidnatrium;sodium nitroprussat
CAS:	14402-89-2

Section 1 - Chemical Product MSDS Name:Sodium Nitroprusside Material Safety Data Sheet
Synonym:Disodium nitrosylpentacyanoferrate; nipride; nitroprussidnatrium;sodium nitroprussat

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
14402-89-2	Sodium nitroprusside	100	238-373-9

Hazard Symbols: T+
Risk Phrases: 28 36

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Very toxic if swallowed. Irritating to eyes.Toxic.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
The toxicological properties of this substance have not been fully investigated.
Inhalation:
Dust is irritating to the respiratory tract. May cause cardiac abnormalities.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Get medical aid.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
None Antidote: None reported

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
NFPA Rating: Not published.
Explosion Limits, Lower: Not available.
Upper: Not available.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Wash hands before eating. Use only in a well ventilated area. Minimize dust generation and accumulation.
Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134. Always use a NIOSH-approved respirator when necessary.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Appearance: clear dark red
Odor: Not available.
pH: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Evaporation Rate: Not applicable.
Viscosity: Not applicable.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Decomposition Temperature: Not available.
Solubility: 40% @ 20 C
Specific Gravity/Density: 1.72
Molecular Formula: C5FeN6Na2O
Molecular Weight: 261.8662

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, toxic fumes of sodium oxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 14402-89-2: LJ8750000 LD50/LC50:
CAS# 14402-89-2: Oral, mouse: LD50 = 61 mg/kg; Oral, rabbit: LD50 = 34 mg/kg; Oral, rat: LD50 = 99 mg/kg.
Carcinogenicity:
Sodium nitroprusside - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
For further information, contact Fisher Scientific.

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

CDG/CPL
Shipping Name: TOXIC SOLID, INORGANIC, NOS (Sodium nitroprusside)
Hazard Class: 6.1
UN Number: 3288
Packing Group: II
IMO
No information available.
IATA
No information available.
RID/ADR
No information available.
Canadian TDG
Shipping Name: POISONOUS SOLIDS NOS (SODIUM NITROPRUSSIDE)
Hazard Class: 6.1(9.2)
UN Number: UN2811

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+
Risk Phrases:
R 28 Very toxic if swallowed.
R 36 Irritating to eyes.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 45 In case of accident of if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 14402-89-2:
Canada
CAS# 14402-89-2 is listed on Canada's DSL/NDSL List.
This product has a WHMIS classification of D1B, D2B.
CAS# 14402-89-2 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
US FEDERAL
TSCA
CAS# 14402-89-2 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

[1]. Wink, D.A., et al., The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: a direct correlation between nitric oxide formation and protection. Arch Biochem Biophys, 1996. 331(2): p. 241-8.

[2]. Garg, U.C. and A. Hassid, Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest, 1989. 83(5): p. 1774-7.

[3]. Namazi, H., Sodium nitroprusside as a nitric oxide donor in a rat intestinal ischemia reperfusion model: a novel molecular mechanism. Clinics (Sao Paulo), 2008. 63(3): p. 405.

Sodium nitroprusside 硝普钠; Ro 21-2498,99.0%

Sodium nitroprusside 硝普钠; Ro 21-2498

化学品安全说明书(MSDS)

质检证书(COA)

在线咨询