硝普酸钠, AR|Sodium Nitroprusside|cas:14402-89-2|西域试剂

硝普酸钠, AR,Sodium Nitroprusside

产品编号：西域试剂-WR363641| CAS NO：14402-89-2| 分子式：C₅FeN₆Na₂O| 分子量：261.92

Sodium Nitroprusside是血管舒张剂，能促使NO释放于血液中。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
西域试剂-WR363641	￥48.00	杭州北京（现货）
西域试剂-WR363641	￥145.00	杭州北京（现货）
西域试剂-WR363641	￥462.00	杭州北京（现货）
西域试剂-WR363641	￥1430.00	杭州北京（现货）

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产品名称

硝普酸钠, AR

英文名称

Sodium Nitroprusside

CAS编号

14402-89-2

产品描述

Sodium Nitroprusside是血管舒张剂，能促使NO释放于血液中。

产品密度

1.72

精确质量

261.92800

PSA

148.38000

LogP

0.29850

外观性状

Liquid | Clear tan-gold

溶解性数据

In Vitro:

H₂O : 100 mg/mL (381.80 mM; Need ultrasonic)

DMSO : 33.33 mg/mL (127.25 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.8180 mL	19.0898 mL	38.1796 mL
5 mM	0.7636 mL	3.8180 mL	7.6359 mL
10 mM	0.3818 mL	1.9090 mL	3.8180 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (381.80 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (9.54 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.54 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
3.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (9.54 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (9.54 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在西域网站选购。

化学品安全说明书(MSDS)

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质检证书(COA)

相关产品

危害码 (欧洲)	T: Toxic;
风险声明 (欧洲)	25
安全声明 (欧洲)	45
危险品运输编码	UN 3288 6.1/PG 3
WGK德国	3
RTECS号	LJ8925000
包装等级	III
危险类别	6.1(b)

Name:	Sodium Nitroprusside Material Safety Data Sheet
Synonym:	Disodium nitrosylpentacyanoferrate; nipride; nitroprussidnatrium;sodium nitroprussat
CAS:	14402-89-2

Section 1 - Chemical Product MSDS Name:Sodium Nitroprusside Material Safety Data Sheet
Synonym:Disodium nitrosylpentacyanoferrate; nipride; nitroprussidnatrium;sodium nitroprussat

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
14402-89-2	Sodium nitroprusside	100	238-373-9

Hazard Symbols: T+
Risk Phrases: 28 36

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Very toxic if swallowed. Irritating to eyes.Toxic.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
The toxicological properties of this substance have not been fully investigated.
Inhalation:
Dust is irritating to the respiratory tract. May cause cardiac abnormalities.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Get medical aid.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
None Antidote: None reported

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
NFPA Rating: Not published.
Explosion Limits, Lower: Not available.
Upper: Not available.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Wash hands before eating. Use only in a well ventilated area. Minimize dust generation and accumulation.
Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134. Always use a NIOSH-approved respirator when necessary.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Appearance: clear dark red
Odor: Not available.
pH: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Evaporation Rate: Not applicable.
Viscosity: Not applicable.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Decomposition Temperature: Not available.
Solubility: 40% @ 20 C
Specific Gravity/Density: 1.72
Molecular Formula: C5FeN6Na2O
Molecular Weight: 261.8662

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, toxic fumes of sodium oxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 14402-89-2: LJ8750000 LD50/LC50:
CAS# 14402-89-2: Oral, mouse: LD50 = 61 mg/kg; Oral, rabbit: LD50 = 34 mg/kg; Oral, rat: LD50 = 99 mg/kg.
Carcinogenicity:
Sodium nitroprusside - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
For further information, contact Fisher Scientific.

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

CDG/CPL
Shipping Name: TOXIC SOLID, INORGANIC, NOS (Sodium nitroprusside)
Hazard Class: 6.1
UN Number: 3288
Packing Group: II
IMO
No information available.
IATA
No information available.
RID/ADR
No information available.
Canadian TDG
Shipping Name: POISONOUS SOLIDS NOS (SODIUM NITROPRUSSIDE)
Hazard Class: 6.1(9.2)
UN Number: UN2811

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+
Risk Phrases:
R 28 Very toxic if swallowed.
R 36 Irritating to eyes.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 45 In case of accident of if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 14402-89-2:
Canada
CAS# 14402-89-2 is listed on Canada's DSL/NDSL List.
This product has a WHMIS classification of D1B, D2B.
CAS# 14402-89-2 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
US FEDERAL
TSCA
CAS# 14402-89-2 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

[1]. Wink, D.A., et al., The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: a direct correlation between nitric oxide formation and protection. Arch Biochem Biophys, 1996. 331(2): p. 241-8.

[2]. Garg, U.C. and A. Hassid, Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest, 1989. 83(5): p. 1774-7.

[3]. Namazi, H., Sodium nitroprusside as a nitric oxide donor in a rat intestinal ischemia reperfusion model: a novel molecular mechanism. Clinics (Sao Paulo), 2008. 63(3): p. 405.