Atpenin A5,99.42%
产品编号:Bellancom-126653| CAS NO:119509-24-9| 分子式:C15H21Cl2NO5| 分子量:366.24
Atpenin A5是一种有效且高度特异的复合物II抑制剂(IC50~10 nM),是一种有效的mKATP通道激动剂和心脏保护剂。
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用,
Atpenin A5
| 产品介绍 | Atpenin A5 是一种有效且高度特异性的 complex II 抑制剂,IC50 为 ~10 nM,且是一种有效的 mKATP 通道激动剂和心脏保护剂。 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 生物活性 | Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), and is an effective mKATP channel agonist and cardioprotective agent.  | ||||||||||||||||
| 体外研究 |                                         
                                        
                                             Atpenin A5 shows the inhibition profile for submitochondrial particles (SMPs), mitochondria, and cardiomyocytes, with IC50 values of 8.3, 9.3, and 8.5 nM, respectively. Atpenin A5 (AA5) is a potent and specific complex II inhibitor. Atpenin A5 (1 nM) also activates the mKATP channel and protects against simulated ischemia-reperfusion (IR) injury in isolated cardiomyocytes. 西域 has not independently confirmed the accuracy of these methods. They are for reference only.  | ||||||||||||||||
| 体内研究 |                                         
                                        
                                             Atpenin A5 is a potent inhibitor of succinate dehydrogenase (SDH). Succinate dehydrogenase inhibition by Atpenin A5 promotes cardiomyocyte mitosis and regeneration in the postnatal heart after myocardial infarction (MI). Atpenin A5-injected mice demonstrated myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. 
  | ||||||||||||||||
| 体内研究 |                                         
                                        
                                             Atpenin A5 is a potent inhibitor of succinate dehydrogenase (SDH). Succinate dehydrogenase inhibition by Atpenin A5 promotes cardiomyocyte mitosis and regeneration in the postnatal heart after myocardial infarction (MI). Atpenin A5-injected mice demonstrated myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. 
  | ||||||||||||||||
| 性状 | Solid | ||||||||||||||||
| 溶解性数据 | 
                                        
                                             In Vitro:  
                                            DMSO : 100 mg/mL (273.04 mM; Need ultrasonic) 配制储备液 
                                                
 
 
                                                    *
                                                     
                                            
                                        
                                        
                                            请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 
                                            请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: 
                                                    ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
                                                        以下溶剂前显示的百 
  | ||||||||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere.  | ||||||||||||||||
| 储存方式 | 
                                 -20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)  | ||||||||||||||||
| 参考文献 | 
  | 
 有竞争力的价格匹配竞争对手的价格
 极速物流效率为先
技术支持专业经验 贴心服务
 现货库存50000+库存
                            
                                                  
                                                          
                                                          
                                                          
                                                          
                                                          
                                                          
                                                          
                                                          
                                                          
                                                          
                                                          
                                                          
                                                          
                                                          
                                                          
                                                          
                                                        
 
浙公网安备 33010802013016号