MX1013 CV1013; Z-VD-FMK|cas:582316-00-5|西域试剂

MX1013 CV1013; Z-VD-FMK,96.32%

产品编号：Bellancom-10397A| CAS NO：582316-00-5| 分子式：C₁₈H₂₃FN₂O₆| 分子量：382.38

MX1013是一种有效的、不可逆的二肽半胱天冬酶抑制剂，具有抗凋亡活性。MX1013以30 nM的IC50抑制重组人半胱氨酸蛋白酶3。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-10397A	￥700.00	杭州北京（现货）
Bellancom-10397A	￥1100.00	杭州北京（现货）
Bellancom-10397A	￥2000.00	杭州北京（现货）
Bellancom-10397A	￥3200.00	杭州北京（现货）
Bellancom-10397A	￥4800.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

MX1013 CV1013; Z-VD-FMK

产品介绍

MX1013 是一种有效的、不可逆的二肽 caspase 抑制剂，具有抗细胞凋亡活性。MX1013 抑制重组人caspase 3，IC₅₀为 30 nM。

生物活性

MX1013 is a potent, irreversible dipeptide caspase inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC₅₀ of 30 nM.

体外研究

MX1013 inhibits caspases 1, 3, 6, 7, 8, and 9, with IC₅₀ values ranging from 5 to 20 nm. MX1013 is selective for caspases, and is a poor inhibitor of noncaspase proteases, such as cathepsin B, calpain I, or Factor Xa (IC₅₀ values >10 μm).
MX1013 inhibits three key markers of apoptosis: the proteolytic maturation of caspase 3, the caspase-mediated cleavage of PARP, and the fragmentation of genomic DNA.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	Jurkat T-lymphocytes
Concentration:	0, 0.05, 0.1, 0.25, 0.5 μM
Incubation Time:	Preincubated for 2 h
Result:	Neither caspase 3 processing nor PARP cleavage could be detected at 0.5 μM. At concentrations of 0.05 μM, caspase 3 processing and PARP cleavage were still markedly reduced.

体内研究
(In Vivo)

MX1013 is an effective antiapoptotic agent in vivo. MX1013 not only inhibits local tissue apoptosis, but also can protect animals against its lethal effects.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female ND4 Swiss Webster mice (16.5-21 g)
Dosage:	0, 0.25, 1, 10 mg/kg (formulated in an aqueous vehicle containing 50 mm Tris-HCl, pH 8.0)
Administration:	Injected i.v.
Result:	The lowest dose of 0.25 mg/kg protected 66% of the mice from the lethal effects of anti-Fas antibody at the 3 h time point, and 1 and 10 mg/kg dose protected 100% of the mice at the 3 h time point.

体内研究

MX1013 is an effective antiapoptotic agent in vivo. MX1013 not only inhibits local tissue apoptosis, but also can protect animals against its lethal effects.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female ND4 Swiss Webster mice (16.5-21 g)
Dosage:	0, 0.25, 1, 10 mg/kg (formulated in an aqueous vehicle containing 50 mm Tris-HCl, pH 8.0)
Administration:	Injected i.v.
Result:	The lowest dose of 0.25 mg/kg protected 66% of the mice from the lethal effects of anti-Fas antibody at the 3 h time point, and 1 and 10 mg/kg dose protected 100% of the mice at the 3 h time point.

体内研究

MX1013 is an effective antiapoptotic agent in vivo. MX1013 not only inhibits local tissue apoptosis, but also can protect animals against its lethal effects.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female ND4 Swiss Webster mice (16.5-21 g)
Dosage:	0, 0.25, 1, 10 mg/kg (formulated in an aqueous vehicle containing 50 mm Tris-HCl, pH 8.0)
Administration:	Injected i.v.
Result:	The lowest dose of 0.25 mg/kg protected 66% of the mice from the lethal effects of anti-Fas antibody at the 3 h time point, and 1 and 10 mg/kg dose protected 100% of the mice at the 3 h time point.