Mitonafide NSC 300288|cas:54824-17-8|西域试剂

Mitonafide NSC 300288,99.79%

产品编号：Bellancom-119182| CAS NO：54824-17-8| 分子式：C₁₆H₁₅N₃O₄| 分子量：313.31

米托那非(NSC 300288)是一种细胞抑制剂。米托那非通过插层与双链DNA结合,并抑制DNA和RNA合成。米托那非是一种抗肿瘤药物,可用于癌症研究,如非小细胞肺癌(NSCLC)、白血病。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-119182	￥800.00	杭州北京（现货）
Bellancom-119182	￥1300.00	杭州北京（现货）
Bellancom-119182	￥2500.00	杭州北京（现货）
Bellancom-119182	￥4000.00	杭州北京（现货）
Bellancom-119182	￥6500.00	杭州北京（现货）

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Mitonafide NSC 300288

产品介绍

Mitonafide (NSC 300288) 是一种细胞生长抑制剂。Mitonafide 通过嵌入 DNA 而与双链 DNA 结合，抑制 DNA 和 RNA 的合成。Mitonafide 是一种抗肿瘤剂，可用于癌症研究，如非小细胞肺癌 (NSCLC)、白血病。

生物活性

Mitonafide (NSC 300288) is a cytostatic agent. Mitonafide binds to double-stranded DNA through intercalation, and inhibits DNA and RNA synthesis. Mitonafide is an antitumor agent that can be used in the research of cancers, such as non-small cell lung cancer (NSCLC), leukemia.

体外研究

Mitonafide inhibits DNA and RNA synthesis and induces single-strand breaks in the DNA of chinese hamster ovary cells.
The incubation of Mitonafide with rat liver microsomes and NADPH under anaerobic conditions results in the formation of a metabolite identified as 5-aminomitonafide.
Mitonafide (25, 50 μM, 1 h) induces single-stand breaks in the DNA of L1210 cells.
Mitonafide (10-100 μM) exhibits cytotoxic effect in the HOP-62 lung cell line^[4].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[6]

Cell Line:	SK-OV-3, HepG2, A-549, T-24, SMMC-7721, HL-7702
Concentration:	0-100 μM respectively.
Incubation Time:	48 h
Result:	Inhibited cell viability with IC₅₀ values of 6.26, 10.88, 7.94, 5.01, 6.94, 8.51 μM.

体内研究
(In Vivo)

Mitonafide (0.5 and 1 mg/kg, i.p., 1-7 days) shows antitumoral potency in S-180 bearing mice^[4].
Mitonafide (5 mg/kg, i.p., twice a day) shows anticancer activity in HepG2 xenograft model^[6].
Mitonafide (single i.p. injection, S-180 bearing mice) shows the LD₅₀ value of 10.0 mg/kg^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	S-180 bearing mice^[4]
Dosage:	0.5 mg/kg and 1 mg/kg
Administration:	Intraperitoneal injection (i.p.) for 1-7 days
Result:	Increased in median survival times.

Animal Model:	HepG2 xenograft model ^[6]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection (i.p.), twice a day.
Result:	Exhibited a relative tumor increment rates (T/C) value of 28.8%.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	S-180 bearing mice^[4]
Dosage:	0.5 mg/kg and 1 mg/kg
Administration:	Intraperitoneal injection (i.p.) for 1-7 days
Result:	Increased in median survival times.

Animal Model:	HepG2 xenograft model ^[6]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection (i.p.), twice a day.
Result:	Exhibited a relative tumor increment rates (T/C) value of 28.8%.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	S-180 bearing mice^[4]
Dosage:	0.5 mg/kg and 1 mg/kg
Administration:	Intraperitoneal injection (i.p.) for 1-7 days
Result:	Increased in median survival times.

Animal Model:	HepG2 xenograft model ^[6]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection (i.p.), twice a day.
Result:	Exhibited a relative tumor increment rates (T/C) value of 28.8%.

性状

Solid

溶解性数据

In Vitro:

DMSO : 62.5 mg/mL (199.48 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1917 mL	15.9586 mL	31.9173 mL
5 mM	0.6383 mL	3.1917 mL	6.3835 mL
10 mM	0.3192 mL	1.5959 mL	3.1917 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式