紫云英苷|Astragaline|cas:480-10-4|西域试剂

紫云英苷,Astragaline,≥99%(HPLC)

产品编号：西域试剂-WR344310| CAS NO：480-10-4| MDL NO：MFCD00075932| 分子式：C₂₁H₂₀O₁₁| 分子量：448.38

Astragalin (Astragaline) 是一种具有抗炎、抗氧化、抗癌、抑菌活性的黄酮类化合物。Astragalin 抑制癌细胞增殖和迁移，诱导细胞凋亡 (apoptosis)。Astragalin 具有口服活性，具有保护神经和心脏，抵抗骨质疏松的作用。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
西域试剂-WR344310	￥750.00	杭州北京（现货）
西域试剂-WR344310	￥1300.00	杭州北京（现货）
西域试剂-WR344310	￥2500.00	杭州北京（现货）
西域试剂-WR344310	￥3800.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

产品名称

紫云英苷

英文名称

Astragaline

CAS编号

480-10-4

产品描述

产品熔点

223-229ºC

产品沸点

823.2±65.0 °C at 760 mmHg

产品密度

1.8±0.1 g/cm3

产品闪点

291.6±27.8 °C

精确质量

448.100555

PSA

190.28000

LogP

1.95

外观性状

黄色针状结晶

蒸气压

0.0±3.1 mmHg at 25°C

折射率

1.774

溶解性

易溶于DMSO，甲醇氯仿的混合溶剂，可溶于热甲醇，不溶于石油醚。

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (223.03 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2303 mL	11.1513 mL	22.3025 mL
5 mM	0.4461 mL	2.2303 mL	4.4605 mL
10 mM	0.2230 mL	1.1151 mL	2.2303 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 1% CMC-Na/saline water
Solubility: 10 mg/mL (22.30 mM); Suspended solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (5.58 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.58 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
3.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.58 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.58 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
4.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.58 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (5.58 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在西域网站选购。

体外研究

Astragalin (0-80 μg/mL; 24 h, 48 h, 72 h) inhibits cancer cells viability and migration at 20, 40, 80 μM, and shows no cytotoxicity to normal human colon epithelial cell lines NCM460.
Astragalin (80 μg/mL; 4 h, 8 h) interrupts the NF-κB signaling pathway and inhibits NF-κB P65 transcriptional activity in HCT116 cells stimulated by TNF-α.
Astragalin (20, 40, 80 μg/mL; 48 h) induces HCT116 cells apoptosis and arrests cell cycle at G0/G1 phase
Astragalin (20, 40, 80 μg/mL; 48 h) increases the level of apoptin in HCT116 and decreases the level of anti-apoptotic proteins in a dose-dependent manner.

XIYU has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	Human colon cancer cell lines (HCT116, LoVo, SW620, SW480, Caco2) and human colon epithelial cell lines NCM460
Concentration:	0, 5, 10, 20, 40, 80 μg/mL
Incubation Time:	24, 48, 72 hours
Result:	Inhibits cancer cells (LoVo, SW620, SW480, Caco2, HCT116) activity at 20, 40, 80 μM. Inhibited HCT116 cells with IC₅₀s of 121.845, 87.908, 18.883 μg/mL at 24, 48, 72 hours, respectively. Showed no cytotoxicity with NCM460 cells.

Cell Cycle Analysis

Cell Line:	Human colon cancer cell HCT116
Concentration:	0, 20, 40, 80 μg/mL
Incubation Time:	48 hours
Result:	Arrested cell cycle at G0/G1.

Western Blot Analysis

Cell Line:	Human colon cancer cell HCT116
Concentration:	80 μg/mL; pre-treated with 20 ng/mL TNF-α
Incubation Time:	4 or 8 hours
Result:	Increased the expression of pro-apoptotic proteins (caspase 3, caspase 6, caspase 7, caspase 8, caspase 9, P53, and Bax) and decreased the expression of anti-apoptotic proteins (cleaved caspase-3 and Bcl-2) in a dose-dependent manner.

Cell Migration Assay

Cell Line:	Human colon cancer cell HCT116
Concentration:	0, 20, 40, 80 μg/mL
Incubation Time:	24, 48, 72 hours
Result:	Reduced release of MMP-2 and MMP-9 enzymes. Inhibited cell migration with mobilities of 14.38, 13.44, and 5.29% with 20, 40, and 80 μg/mL concentrations, respectively.

体内研究

Astragalin (25, 50, and 75 mg/kg; p.o.; once every two days; 25 d) reduces the tumor volumes, tumor weight and tumor formation rates and decreases expression of p-NFκB and p-iκκα in nude mouse model with human colon cancer.

XIYU has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male BALB/c nude mice (4-week-old) with HCT116 cells (s.c.)
Dosage:	0 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg
Administration:	Oral gavage; once every two days; for 25 days
Result:	Resulted tumor inhibition rates of 17.43%, 34.89% (p < 0.01), and 67.06% with 25 mg/kg, 50 mg/kg, 75 mg/kg dose administration. Showed no effect on mouse weight.

动物实验

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.2303 mL	11.1513 mL	22.3025 mL
5 mM	0.4461 mL	2.2303 mL	4.4605 mL
10 mM	0.223 mL	1.1151 mL	2.2303 mL

不同实验动物依据体表面积的等效剂量转换表（参考来源于公开文献）

	小鼠	大鼠	兔	豚鼠	仓鼠	狗
重量 (kg)	0.02	0.15	1.8	0.4	0.08	10
体表面积 (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m 系数	3	6	12	8	5	20

动物 A (mg/kg) = 动物 B (mg/kg) ×	动物 B的K_m系数
	动物 A的K_m系数

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

储存条件

储存条件: -20°C

运输方式: 冰袋运输，根据产品的不同，可能会有相应调整。

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

安全声明 (欧洲)	22
危险品运输编码	NONH for all modes of transport
RTECS号	DJ3080000

1. 物质的识别

产品名：	Astragalin
CAS号：	480-10-4
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Astragalin
别名：	Astragaline; 3-Glucosylkaempferol; Kaempferol 3-β-D-glucopyranoside
分子式：	C21H20O11
分子量：	448.38

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

上游产品 6
133-89-1 520-18-3 152390-63-1 56317-05-6
23405-70-1 96333-59-4
下游产品 8
59-23-4 520-18-3 10257-28-0 99-96-7
50-99-7 2280-44-6 492-61-5 108-73-6

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