黄芩素, 分析对照品, ≥99%|Baicalein|cas:491-67-8|西域试剂

黄芩素, 分析对照品, ≥99%,Baicalein

产品编号：西域试剂-WR344739| CAS NO：491-67-8| MDL NO：MFCD00017459| 分子式：C₁₅H₁₀O₅| 分子量：270.24

Baicalein（5,6,7-Trihydroxyflavone，Noroxylin，黄芩素）是一种存在于黄芩，木蝴蝶，百里香等植物中的天然黄酮类化合物，具有抗炎和抗癌活性。Baicalein可明显抑制PI3K/Akt/NF-κB途径，同时也可通过上调GPX4，抑制黑素细胞的铁死亡（ferroptosis），用于白癜风和肿瘤的相关研究。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
西域试剂-WR344739		￥116.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

产品名称

黄芩素, 分析对照品, ≥99%

英文名称

Baicalein

CAS编号

491-67-8

产品描述

产品熔点

256-271 °C(lit.)

产品沸点

575.9±50.0 °C at 760 mmHg

产品密度

1.5±0.1 g/cm3

产品闪点

225.3±23.6 °C

精确质量

270.052826

PSA

90.90000

LogP

3.31

外观性状

黄色结晶固体

蒸气压

0.0±1.7 mmHg at 25°C

折射率

1.732

溶解性

DMSO : 50 mg/mL (185.02 mM; Need ultrasonic)

溶解性数据

In Vitro:

DMSO : 50 mg/mL (185.02 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7004 mL	18.5021 mL	37.0041 mL
5 mM	0.7401 mL	3.7004 mL	7.4008 mL
10 mM	0.3700 mL	1.8502 mL	3.7004 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 0.5% CMC-Na/saline water
Solubility: 20 mg/mL (74.01 mM); Suspended solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: 2.5 mg/mL (9.25 mM); Clear solution; Need ultrasonic

此方案可获得 2.5 mg/mL (9.25 mM) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
3.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (9.25 mM); Clear solution; Need ultrasonic

此方案可获得 2.5 mg/mL (9.25 mM) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在西域网站选购。

靶点

IC50: 3.12 mM (xanthine oxidase)

体外研究

体外研究：Baicalein体外抑制促分裂原诱导的T细胞增殖和细胞因子分泌。黄芩苷的预处理显着抑制Con A或抗CD3 / CD28 mAb诱导的增殖以及25μM细胞因子分泌。黄芩苷处理诱导NF-κB的DNA结合，但抑制核隔室中的硫氧还蛋白活性。黄芩苷以时间和剂量依赖的方式抑制MDA-MB-231细胞的增殖，迁移和侵袭。黄芩素显着降低MDA-MB-231细胞中SATB1的表达。 Baicalein也下调Wnt1和β-连环蛋白的表达以及Wnt /β-连环蛋白靶向基因的转录水平。体内研究：黄芩苷抑制移植物抗宿主病的诱导，但不抑制小鼠T细胞的体内平衡增殖。这一观察清楚地显示了黄芩素在体内的有效抗炎活性。保护用黄芩苷治疗的大鼠免受心脏与体重比的增加，脑利钠肽的血浆水平，脑室内隔膜厚度，左心室的心肌胶原体积（均分别为P <0.05）。黄芩苷的抗纤维化作用进一步通过抑制左心室前胶原I和III的表达，伴随着12-脂肪氧合酶的表达降低以及基质金属肽酶9和细胞外信号调节激酶的表达和活性的降低而进一步说明。黄芩苷可以抑制高血压大鼠的心脏纤维化。

体内研究

黄芩素抑制移植物抗宿主病的诱导，但不抑制小鼠体内T细胞的稳态增殖。该观察结果清楚地显示了黄芩素在体内的有效抗炎活性。用黄芩素处理的大鼠受到保护，以防止心脏与体重比，脑利钠肽的血浆水平，室内隔膜厚度，左心室的心肌胶原体积的增加（分别均为P <0.05）。黄芩素的抗纤维化作用通过抑制左心室前胶原I和III的表达以及12-脂氧合酶的表达降低以及基质金属肽酶9和细胞外信号调节激酶的表达和活性降低进一步说明。黄芩素可抑制高血压大鼠的心肌纤维化。

细胞实验

进行MTT测定以评估黄芩素对乳腺癌细胞增殖的影响。常规消化，收集MDA-MB-231细胞，然后以8×103细胞/孔的密度接种在96孔板中。孵育12-24小时后，根据实验分组，用0,20,40,60,80,100和120μM黄芩素处理细胞，然后在37℃下孵育24,48和72小时。 ]。

动物实验

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.7004 mL	18.5021 mL	37.0041 mL
5 mM	0.7401 mL	3.7004 mL	7.4008 mL
10 mM	0.37 mL	1.8502 mL	3.7004 mL

不同实验动物依据体表面积的等效剂量转换表（参考来源于公开文献）

	小鼠	大鼠	兔	豚鼠	仓鼠	狗
重量 (kg)	0.02	0.15	1.8	0.4	0.08	10
体表面积 (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m 系数	3	6	12	8	5	20

动物 A (mg/kg) = 动物 B (mg/kg) ×	动物 B的K_m系数
	动物 A的K_m系数

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

稳定性

按规格使用和贮存，不会发生分解，避免与氧化物接触

储存条件

2-8°C下密封保存，放置在通风，干燥的环境中

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

符号	GHS07
信号词	Warning
危害声明	H315-H319-H335
警示性声明	P261-P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xi: Irritant;
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	S26-S36
危险品运输编码	NONH for all modes of transport
WGK德国	3
海关编码	2932999099

1. 物质的识别

产品名：	Baicalein
CAS号：	491-67-8
制造商/供应商：	西域试剂网站：www.hzbp.cn 邮件：13911702513@139.com

2. 合成/成分数据

产品名：	Baicalein
别名：	5,6,7-Trihydroxyflavone
分子式：	C15H10O5
分子量：	270.24

3. 急救措施

吸入后：	如果吸入，移至空气新鲜处，如果呼吸困难，给输氧，如呼吸停止，给予人工呼吸。
皮肤接触后：	用大量的水冲洗，移除污染的衣服和鞋子。
眼睛接触后：	检查并取下隐形眼镜，并用大量的水冲洗；呼叫医生。
吞食后：	如果吞食，用大量纯净水漱口；呼叫医生。

4. 消防措施

适当的灭火剂：	雾状水，二氧化碳，干粉或泡沫。
防护设备：	穿戴自给式呼吸器和防护服，以防止与皮肤和眼睛接触。

5. 泄漏应急处理

安全防范措施：	封锁泄漏区域；穿戴自给式呼吸器，防护服和厚橡胶手套。
清洁/收集措施：	使用液体粘合原料（硅藻土，通用粘合剂）吸取精细粉末；使用酒精擦洗表面和设备除去污渍；根据第11条处理被污染的材料。

6. 处理和储存

安全处理说明：	避免吸入和接触皮肤，眼睛及衣物；材料可能略微具有刺激性。
储存：	2-8°C, protect from light

7. 接触控制和个人防护

呼吸设备：	NIOSH / MSHA认可的呼吸器。
双手保护：	耐化学腐蚀的橡胶手套。
眼睛防护：	化学安全护目镜。

8. 稳定性和反应活性

稳定性：	按照说明存储是稳定的；避免强氧化剂。
热分解/其他要避免的情况：	避免光和热。

9. 毒性资料

急性毒性：	无可用资料。
主要刺激性影响：	无可用资料。
在皮肤上：	无可用资料。
对眼睛：	无可用资料；可能具有刺激性。

10. 生态资料

一般注意事项：

无可用资料。

11. 废弃处置

按照所在国家，省份，县市和地方的法规处置。

12. 运输信息

正确的运输名称：	无
非危险品运输：	这种物质被视为非危险品运输。

13. 法规信息

尚未有针对此产品作出的化学安全性评估。

14. 其他信息

上游产品 10
973-67-1 29550-13-8 21967-41-9 480-11-5
671791-94-9 67047-05-6 28279-72-3 150036-33-2
642-71-7 412027-80-6
下游产品 8
480-11-5 740-33-0 2035-05-4 29550-13-8
973-67-1 3162-43-4 21967-41-9 73202-52-5

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