MSA-2, 98%,MSA-2
产品编号：西域试剂-WR146942| CAS NO：129425-81-6| 分子式：C14H14O5S| 分子量：294.32
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，
| 用途: | MSA-2 is an orally available human STING agonist.MSA-2 is bound to STING as a noncovalent dimer. Extensive experimental analysis indicates that MSA-2 predimerization is required for binding. Acidic tumor microenvironments favor permeable, uncharged MSA-2. Intracellular MSA-2 is "trapped" and accumulation drives MSA-2 dimerization, preferentially activating STING intratumorally. Orally dosed MSA-2 is well tolerated in mice, exhibiting STING-dependent antitumor activity, as monotherapy and combined with antibodies against PD1 (anti-PD1). |
|---|---|
| 储存条件: | -20°C，密闭，干燥 |
| 物化性质: | |
| 熔点: | |
| 沸点: | |
| 密度: |
相关文档
化学品安全说明书(MSDS)
下载MSDS质检证书(COA)
相关产品
浙公网安备 33010802013016号