盐酸脱水四环素, 99%|Anhydrotetracycline Hydrochloride|cas:13803-65-1|西域试剂

盐酸脱水四环素, 99%,Anhydrotetracycline Hydrochloride

产品编号：西域试剂-WR45612| CAS NO：13803-65-1| MDL NO：MFCD00151453| 分子式：C₂₂H₂₃ClN₂O₇| 分子量：462.88

盐酸脱水四环素是四环素生物合成的前体，是一种有效的竞争性广谱四环素破坏酶抑制剂。盐酸脱水四环素是真核细胞中四环素控制基因表达系统的效应剂。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
西域试剂-WR45612	￥1081.00	杭州北京（现货）
西域试剂-WR45612	￥2623.00	杭州北京（现货）
西域试剂-WR45612	￥9438.00	杭州北京（现货）

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英文名称

Anhydrotetracycline Hydrochloride

CAS编号

13803-65-1

产品描述

产品熔点

222.8ºC

产品沸点

618.6ºC at 760 mmHg

产品闪点

327.9ºC

精确质量

462.119385

PSA

161.39000

LogP

1.95810

蒸气压

3.66E-16mmHg at 25°C

溶解性数据

In Vitro:

DMSO : 20.83 mg/mL (45.00 mM; ultrasonic and warming and heat to 80°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1604 mL	10.8019 mL	21.6039 mL
5 mM	0.4321 mL	2.1604 mL	4.3208 mL
10 mM	0.2160 mL	1.0802 mL	2.1604 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: 2.08 mg/mL (4.49 mM); Suspended solution; Need ultrasonic

此方案可获得 2.08 mg/mL (4.49 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (4.49 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.49 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在西域网站选购。

体外研究

盐酸脱水四环素对四环素类药物Tet（50）（IC50=210μM）、Tet（X）（IC50=41μM）、Tet（X）3（IC50=3μM）的降解有抑制作用。盐酸脱水四环素对金霉素Tet（50）（IC50=210μM）、Tet（X）（IC50=75μM）、Tet（X）Β3（IC50=26μM）的降解有抑制作用。盐酸脱水四环素抑制去甲氯环素的Tet（50）（IC50=120μM）、Tet（X）（IC50=41μM）、Tet（X）3（IC50=7μM）降解。盐酸脱水四环素对四环素类药物Tet（50）（IC50=210μM）、Tet（X）（IC50=41μM）、Tet（X）3（IC50=3μM）的降解有抑制作用。盐酸脱水四环素对金霉素Tet（50）（IC50=210μM）、Tet（X）（IC50=75μM）、Tet（X）Β3（IC50=26μM）的降解有抑制作用。盐酸脱水四环素抑制去甲氯环素的Tet（50）（IC50=120μM）、Tet（X）（IC50=41μM）、Tet（X）3（IC50=7μM）降解。

稳定性

遵照规定使用和储存则不会分解。

储存条件

储存条件: 2-8°C

运输方式: 冰袋运输，根据产品的不同，可能会有相应调整。

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

相关产品

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲)	Xn
风险声明 (欧洲)	R63
安全声明 (欧洲)	S36/37/39
危险品运输编码	NONH for all modes of transport
海关编码	1702190000

Name:	Anhydrotetracycline Hydrochloride "can be used as Secondary Material Safety Data Sheet
Synonym:	None
CAS:	13803-65-1

Section 1 - Chemical Product MSDS Name:Anhydrotetracycline Hydrochloride "can be used as Secondary Material Safety Data Sheet
Synonym:None

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
13803-65-1	Anhydrotetracycline Hydrochloride	100	unlisted

Hazard Symbols: XN
Risk Phrases: 63

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Possible risk of harm to the unborn child.Light sensitive.Moisture sensitive.Air sensitive.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation. The toxicological properties of this material have not been fully investigated.
Skin:
May cause skin irritation. The toxicological properties of this material have not been fully investigated.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light. Store protected from air. Keep from contact with moist air and steam.
Storage:
Do not store in direct sunlight. Store in a tightly closed container. Store in a dry area. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not expose to air. Store protected from moisture.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 13803-65-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 223 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: N/A
Explosion Limits, upper: N/A
Decomposition Temperature: > 223 deg C
Solubility in water: in water: 1:200 m/v
Specific Gravity/Density:
Molecular Formula: C22H22N2O7.HCl
Molecular Weight: 464.89

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, light, dust generation, moisture, exposure to air, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 13803-65-1 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Anhydrotetracycline Hydrochloride - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 63 Possible risk of harm to the unborn child.
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37 Wear suitable protective clothing and
gloves.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 13803-65-1: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 13803-65-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 13803-65-1 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

4465-65-0

13803-65-1

文献：Journal of the American Chemical Society, , vol. 79, p. 2849,2856

上游产品 1
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下游产品 1
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[1]. Jana L Markley, et al. Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes. ACS Infect Dis. 2019 Apr 12;5(4):618-633.